Real-World Evidence of Anticoagulation Reversal Events Case Study

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Real-World Evidence of Anticoagulation Reversal Events in NOAC Patients: Competitive Intelligence Case Study

A leading pharma company wanted Real-World Evidence (RWE) on anticoagulation reversal events in patients treated with Novel Oral Anticoagulants (NOACs). The objective was to understand the frequency of these reversal events to support access and reimbursement decisions.

You Know How

Access and reimbursement decisions are important for commercialising treatments in the pharma world. Our client needed evidence on the frequency and management of anticoagulation reversal events in patients using NOACs. All necessary for them to demonstrate the need for and effectiveness of reversal agents for payers and regulatory bodies.

What We Did

Our team implemented a comprehensive research methodology to meet the client’s needs:

  1. Data Sources: We utilised the client’s claim and Electronic Health Records (EHR) data.
  2. Inclusion Criteria: We developed specific inclusion criteria to select patients treated with NOACs who experienced reversal events. This ensured a focused and relevant patient cohort for analysis.
  3. Reversal Agent Usage: We analysed the usage rates of reversal agents in the selected patient population, examining the frequency and circumstances under which these agents were used.
  4. Reversal Rates: We calculated the rates of anticoagulation reversal events, providing a clear picture of the prevalence and characteristics of these events in NOAC-treated patients.

What They Got

The client received a detailed and actionable report that included:

  • Comprehensive Analysis: An in-depth analysis of the rates of reversal events and the usage of reversal agents in NOAC-treated patients based on Claims and EHR data.
  • Clear Presentation: A clear presentation of our findings, communicating the frequency of reversal events.
  • Strategic Recommendations: Based on the analysis, support the client’s access and reimbursement strategies.

The Result Was

The insights provided enabled the client to use the evidence to demonstrate the need and usage of reversal agents, facilitating access decisions. They isolated real-world reversal events and associated healthcare resource use.

This case study shows the value of real-world evidence in terms of pharma companies’ access. By delivering a thorough analysis and actionable insights, we helped our client to make decisions to enhance their strategic market position.

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